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KMID : 0665220070200030259
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Korean Journal of Food and Nutrition
2007 Volume.20 No. 3 p.259 ~ p.264
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The Effects of Zingiber officinale Roscoe Extracts on Mouse IFN-γ and IL-10 Production
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Ryu Hye-Sook
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Abstract
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Ginger(Zingiber officinale Roscoe) has been used as a raw material in many various traditional preparations since the ancient times. As a component of traditional health products, ginger is known to be effective as an appetite enhancer, and has anti-cold and anti-inflammatory activities. This study was performed to investigate the immunomodulative effects of Zingiber officinale Roscoe in mice, using ex vivo experiments. In order to elucidate ginger’s immunomodulative effects of Ginger, water extracts were orally administered to mice, and isolated macrophages were used as the experimental model. To identify the ex vivo effects, six to seven week old Balb/c mice were fed a chow diet ad libitum and the ginger water extracts were administered orally every other day for two or four weeks at two different concentrations(50 and 500 mg/kg b.w.). The results show that IL-IO and IFN-γ were detected in the 500 mg/kg b.w. supplemented group with LPS stimulation in all cases. Also, the IFN-γ IL-10 ratio ranged from 3~5 with mitogen stimulation such as Con A and LPS. In conclusion, this study suggests that ginger extracts may enhance the immune function by regulating the cytokine(IL-10 and IFN-γ) production capacity of activated macrophages in mice.
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KEYWORD
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ginger extracts, immunomodulating, IL-10, IFN-γ, proinflammatory, antiinflammatory
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